california kingsnake

Question
i've   had   my   cali   kingsnake   for   8   years   now.   Its   a   female   and   almost   60   inches   long.   Its   shed   its   skin   6   days   ago   and   i   tried   feeding   it   mice   3   days   ago   it  has   ignored   them   for   the  past   3  days.   Its  beocme   overly   active   and  hardly  sleeps.   I  tried  to   let   it  out   to  move around  the  room   and  it  still  behaves  the same.  Its  currently  summer  and the tank  temp  is almost  86  degrees  fahrenheit.  There  is  no  physical  evidence  of  injury  of illness  just a  change in behavior  and refusing  to  eat.  It has  had  food for  2 weeks  due to it  preparing to  shed. I  don't know whether  removing the mice from the cage will help  if they are bothering it

Answer
Never, EVER leave live mice in with a snake unattended.  They can do more than bother it--they can kill it.  Many owners have tragically found that mice are aggressive animals that become predatory when trapped in a cage with another animal.  Snakes will not defend themselves effectively against an aggressive rodent--their instincts tell them to flee, if they aren't hungry.  In a cage, there's no where to flee to.  There are plenty of photos online of snakes with their backs chewed to the bone by mice.

Remove the mice, and clean the tank fully.  It is a bit warm in the tank--really, a kingsnake should have a daytime temperature of about 80F, and a basking area at 90F (no higher).  So, the snake may be looking for a cooler area.

Having had your snake for 8 years, the animal is probably overdue for a vet checkup (unless you already do annual checkups).  You'll want to take it into the vet for a checkup, along with a fresh (not dried out) fecal sample, to have the snake tested for internal parasites.  Mice can occasionally transmit these parasites, so an annual test as part of routine health care is recommended.  

Snakes generally cease eating due to a health issue, incorrect environment/stress, or breeding.  Since your snake is female and it's summer, we can rule out breeding.  (Kingsnakes brumate (similar to hibernation, only awake) during the winter, and breed in spring when temperatures warm up).