Bunny has been diagnosed with aspergillus

Question
She will be 2 in March. She lives with other rescued bunnies . Shestarted having these sneezing / coughing fits . Like 10 or so at a time. We brought her to the vet. She was x-rayed and had blood drawn and also a culture done. The vet was able to get some mucus from her when she was getting ready for the x-ray.First the blood work tested for pasteurella. She is now on baytrill for 14 day. She's on day 6 now. The x-ray showed something in the bronchial tubes but everything else was fine. The culture results cam back and now we find out she has aspergillus too. Now we are waiting to get medication for that. Itraconazole. How safe is itraconazole for bunnies and can it be given at the same time as the baytril ? The weird thing about this is that the bunny seems perfectly healthy. Binkies , running eating , pooping ,etc.. We moved her into a different room when the coughing got bad and now it has almost gone away. She coughs about 1 to 2 times a day. Before they were these bouts of 10 or so right in a row multiple times a day. I'm not a huge fan of medication and putting her on another one has me a little nervous. Especially since I can't seem to find anything about the effects of intraconazole on bunnies.
Thanks.

Answer
Dear Derrick,

Aspergillus is rarely a pathogen, except in very immunocompromised individuals.  I would wonder whether this result is a contaminant in the culture, especially if bun shows no obvious signs of fungal infection in the sinuses.  If she was living in a moldy room, it could be that she inhaled some spores from the environment, and those grew in culture.  

Fungistatic/fungicidal drugs are often to be used with caution.  This one can, at least in humans, reduce production of liver enzymes that normally metabolize foreign substances in the body, such as medications.  That means that the blood levels of some medications can be increased by the itraconazole, sometimes with adverse effects.  (I don't know if itraconazole would increase blood levels of Baytril (enrofloxacin), but if it did, you might see some neurological signs that are ordinarily not permanent, once the blood levels of the drug go down again.)

If this were my bunny, I would ask about holding off on the itraconazole for now, since the coughing seems to have improved when you moved her out of the original room she was in (moldy?).  No sense in medicating her for something that might not actually be causing her problem.

I hope this helps.

Dana