Giving meds to a flighty cat

Question
I am pretty much running out of ideas.  Maggie is a 5-year-old cat, acquired from a rescue organization at about 6 months old, and while she is affectionate, a little purring machine, and loves being petted (on her terms, of course), she has never really liked being handled.  This has made it very hard to give her meds.  She only eats dry food and gets occasional treats.

She's currently supposed to take an antibiotic twice a day and a quarter of a prednisone twice a day.  The latter pill is quite small but the former one is fairly large for an 8 lb cat.  So far I've tried:

1)Crushing pills and mixing with soft treats.  It takes 2 treats just to mix in the crushed pills and the resulting treat is not only too large, but it doesn't hold together either.  She'll nibble a bit but ignore most of it.

2)Mixing in a small amount of canned food.  This worked for a day or two, but then she only ate half or less, then one bite.  I spoon fed her a couple of times but now she's not interested.  It may be that I need to add more food to cover the taste/smell of the crushed meds, though I'm not sure.  I've been trying to keep the amount of food small.

3)We tried Nutrical (it works on our dog), but she's not interested.

4)Pill Pocket treats worked for the small quarter of prednisone but not the larger antibiotic.  In fact, after one of the treats she wasn't interested in any more.

I could grab her and just give her the pills, but I would only be able to do it once.  After that she'd avoid me and be almost impossible to catch or even trick.

So I just don't know what to do anymore.  Baby food?

Answer
They can now make the medications in a transdermal form, where you rub the medicine on the ear and it gets absorbed through the skin.  I would recommend asking your vet to call the Medicine Shoppe or Vetcentric to have the meds formulated this way.

I am not sure why she is on these medications, but another alternative to the twice a day antibiotic would be giving 1/2 of a human 250mg zithromax once and see how she responds to that dose.