How to Kill Fleas on a Guinea Pig. Fleas are a common parasite that are not host-specific. They can attack any pet with fur, including guinea pigs. The most effective method of killing fleas on guinea pigs, according to peteducation.com, is the application of a pyrethrin insecticide, which is the type used on cats. Owners must also treat the guinea pig's surrounding environment to prevent re-infestation.
Brush the guinea pig with a flea comb to check for fleas. If the comb pulls any fleas off the guinea pig, run the comb under the faucet to flush them down the drain.
Purchase a pyrethrin insecticide from your veterinarian, and consult with her about application instructions. The application amount may vary with the weight of your guinea pig.
Remove the guinea pig's bedding and replace it with new bedding. The fleas may have laid eggs in the cage's bedding, and when they hatch they will re-infest the guinea pig.
Wash any cloth toys, beds or other items the guinea pig may sleep on in the washer on the hottest setting.
Vacuum the carpet around the guinea pig's cage thoroughly. Any fleas that jumped off the pet may reside in the carpet.
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