What is aspirin?
Aspirin (acetylsalicylic acid) is a popular non-sterodial anti inflammatory drug (NSAID) that has a number of therapeutic uses including treating fever (antipyretic), reducing inflammation, blood thinning (by preventing the formation of blood clots) and relieving pain (analgesic). Unfortunately, aspirin is also one of the most common causes of poisoning in cats. Unlike humans, cats metabolise aspirin very slowly and it is extremely easy to give a cat a fatal overdose in as little as a single tablet. Aspirin poisoning can occur in cats of all ages, however kittens and senior cats are at greater risk.
Why is aspirin so toxic to cats?
Aspirin is broken down by the liver by an enzyme known as UGT1A6. Cats produce only a minute amount of this enzyme compared to other species, meaning that it takes considerably longer for the body to break down the drug than it would in a human or dog. The biological half life of aspirin in cats is approximately 40 hours compared to 7.5 hours in dogs.
Aspirin poisoning can occur in many ways, such as:
When a pet owner intentionally gives the cat a high dosage of aspirin.
When a pet owner gives a smaller amount of aspirin over a prolonged period. Because cats are not able to metabolise the drug as quickly as other animals, levels quickly build up resulting in toxicity.
When a pet owner accidentally gives a product containing aspirin such as Pepto-Bismol.
Accidental ingestion, such as eating an aspirin dropped on the floor. This is more likely to occur in dogs than cats who tend to be more fussy about what they eat.
Deliberate poisoning.
Aspirin overdose causes inflammation, bleeding, ulceration and perforation of the stomach, bone marrow toxicity, metabolic acidosis and damage to the kidneys and liver.
Symptoms usually begin within 3-6 hours of ingestion, but may be slower to occur if lower doses are given over a period of time. Common symptoms of aspirin poisoning include:
How is aspirin poisoning diagnosed?
Diagnosis is based on a history of exposure to the drug. However, in the case of deliberate poisoning, the pet owner may not be aware that the cat has ingested aspirin.
Tests your veterinarian may perform include:
Prompt diagnosis and treatment are vital if your cat is to recover from aspirin poisoning. There is no antidote, the goal of treatment is to remove the drug from the body and offer supportive care. Treatment will include:
Prognosis:
The prognosis is favourable if treatment commences prior to the onset of symptoms, otherwise it is guarded.
Avoiding aspirin poisoning in cats:
Additional notes:
Aspirin can be used in very small doses to prevent blood clots, reduce fever and relieve pain but only under strict veterinary supervision. It is absolutely vital that cat owners do not self medicate their cat, particularly aspirin because this will most likely have lethal consequences for the cat. The safe dose for cats is 10mg/kg every 48 hours. Aspirin should be used with caution in cats with liver or kidney disease, gastric ulcers, coagulation disorders, asthma, pregnancy and with kittens and senior cats. Any blood thinning medications (including aspirin) should also be stopped 1-2 weeks prior to surgery.
Also see:
Paracetamol (acetaminophen) poisoning in cats Ibuprofen poisoning in cats
Updated 29/9/14.
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